This book qualitatively and quantitatively examines the relationships between the constructed environment, health and social vulnerability. It demonstrates that spatial disintegration is often intertwined with health and social inequalities, and therefore a multidisciplinary approach to urban health is essential in order to analyze the impact that psycho-social-environmental factors can have on objective, and perceived health and to investigate the inequalities in healthcare and medical assistance processes. Empirical relationships have been observed between urban environment, social vulnerability and health in different contexts, however there is still a lack of standardized tools that allow us to gain a clear understanding of how health inequalities and daily life are generated. In order to address this issue, a national network of active research groups has been created to draft and develop a prototypical analysis infrastructure to facilitate empirical studies aimed at shedding light on the complex relationships between health disparities, socio-environmental and economic distress, as well as personal and collective health. Given the interest in achieving meaningful, fair and lasting solutions to health inequalities, and the current lack of an analytical system, there is the need for new multidisciplinary approaches oriented toward the quality of life within a eco-social model of health. Providing an overview of the methodological approaches discussed, this book will appeal to researchers. At the same time it allows those working in local and government social care, healthcare and administrative institutions to gain insights into best practices in urban contexts.