Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence
.
This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.
Toxicology and Epigenetics
reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of
in vivo
and
in vitro
models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.
Topics covered include:
environment, epigenetics and diseases
DNA methylation and toxicogenomics
chromatin at the intersection of disease and therapy
epigenomic actions of environmental arsenicals
environment, epigenetics and cardiovascular health
toxicology, epigenetics and autoimmunity
ocular epigenomics: potential sites of environmental impact in development and disease
nuclear RNA silencing and related phenomena in animals
epigenomics – impact for drug safety sciences
methods of global epigenomic profiling
transcriptomics: applications in epigenetic toxicology
is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.