Set in New Orleans, The Inspiring Mind of a Quixotic Girl tells the story of seventeen year old, Bliss Fontaine, a quixotic girl by nature, as starry-eyed and idealistic as they come. Bliss has been forced to live a sheltered life, being verbally abused by her wealthy, egotistical, neurotic mother. Longing to solve the mystery behind her father's sudden disappearance from her life, Bliss recruits the help of her only friend, her mother's maid, Neely.
Together, they plan their great escape. Escape from the oppression of Bliss' mother, Cecily Fontaine, and escape from what Bliss claims is their certain death, "lack of creative stimulation and suffocation of spirit".
With the help of a dancing hoodoo woman, Bliss and Neely discover the power of freedom and the perseverance of the female spirit.