The Coronavirus outbreak devastated the whole world, posing a major crisis to global leaders. This book analyzes major leadership theories and explores the challenges of leadership during the Coronavirus pandemic with a focus on the United States. It suggests a broader view of leadership in facing the challenges of the pandemic. The book analyzes the complexities of leadership: developing a unified strategy to combat the Coronavirus, coordination among the national actors, the problem of bureaucracy, providing adequate facilities, ensuring safety in travel, protecting the economy, the vulnerable, and educational institutions. The big power rivalry, politics—administration dichotomy, and other important sectors affected by the pandemic are investigated. The book proposes a unified national and international strategy in combating the pandemic and suggests ways to protect the important sectors of society: economy, education, healthcare facilities, and transportation. International politics and public administration issues are uniquely analyzed to understand the challenges of the Coronavirus crisis. The book argues that to understand the complexities of the Coronavirus, one needs to be aware of international politics, the dynamics of the internal political structures, domestic and international politics and suggest ways to take effective actions.