The Caribbean Region is second only to Africa in the impact of HIV and AIDS. The Caribbean Community (CARICOM) has responded to this challenge by promoting a multisectoral response to the epidemic. UNESCO has provided regional leadership in strengthening the education sector component of this response. In 2005, UNESCO launched, with CARICOM and the World Bank, a regioinal dialogue involving representatives of Ministries of Education, national HIV and AIDS coordinating councils, development partners, and regional institutions providing leadership in the HIV response, which led to the development and endorsement of a regional Proposal for Action: Accelerating the Education Sector Response to HIV and AIDS in the Caribbean Region. In June 2006, Ministers of Education and representatives of National AIDS AUthorities met in Port-of-Spain, Trinidad and Tobago, under the auspices of the CARICOM Council on Human and Social Development, and agreed to promote education sector leadership in addressing HIV and AIDS and to create a supportive policy and financial environment at national and regional levels. This report describes the development of these regional processes and how they have led to a stronger education sector response at the regional level. It also focuses on developments in three countries (Guyana, Jamaica, and St. Lucia) as examples of how this regional effort translates into action at the national level.