For quite a while the future has been bleak for Holistic Henry and Cancer Carl and it isn't getting any better. As the government begins to round-up the homeless population for an involuntary mission to space, Henry and Carl attempt to evade capture, fleeing with acquaintances Junkie Julie, Castaway Connie and Bike Mike. But their luck quickly runs out.
Exiled to Mars, thousands of hobos must stick together in their isolation. What the rest of the world sees as opportunity for them, they see as a death sentence. The people in charge have a deadline and don't care what they have to do to meet it.
When Henry learns that his estranged daughter, Lily, is terminally ill, he frantically searches for a way to return to home. Carl reveals an escape route but it will take a revolt by the hobos to make it happen. Henry and Connie orchestrate an uprising but the powers that be see the imminent threat and try to quash it before it can gain momentum.Will Henry and Carl survive not only the harsh living conditions of Mars but live long enough to see their revolution become a reality?