Skeletal muscles are organs found in the vertebrate muscular system that are usually connected to skeleton bones through tendons. It is the most abundant tissue in the human body and it is longer than other muscle tissues. It also has a strong innate ability to repair tissue damage occurred through an accident or degenerative illnesses, like muscular dystrophy, and regenerate new muscle fibers. Satellite cells and myogenic progenitors located between the muscle fiber membrane and the basal lamina are primarily responsible for regeneration. Skeletal muscles have the ability to regenerate and repair themselves following a trauma in a sophisticated and well-organized manner. This process requires the existence of varied cell populations, the up and down regulation of different gene expressions, along with the involvement of numerous growth agents. The topics in this book on the regeneration of skeletal muscles are of utmost significance and bound to provide incredible insights to readers. The readers would gain knowledge that would broaden their perspective in this area of orthopedics.