In the 1920s and 1930s most Chinese people suffered from overwhelming health problems. Epidemic diseases killed tens of millions, drought, flood and famine killed many more, and unhygienic birthing led to serious maternal and child mortality. The Civil War between Nationalist and Communist forces, and the nationwide War of Resistance against Japan (1937-1945), imposed a further tide of misery. Troubled by this extensive trauma, a small number of healthcare reformers were able to save tens of thousands of lives, promote hygiene and sanitation, and begin to bring battlefield casualties, communicable diseases, and maternal child mortality under control. This study shows how biomedical physicians and public health practitioners were major contributors to the rise of modern China.