This comprehensive guide delves into the significance of root canal morphology & variations in endodontic therapy. With a focus on the latest research and clinical applications, this book explores the prevalence and types of canal variation which is mostly seen in mandibular premolar teeth. With the use of advance diagnostic techniques like CBCT, the impact of canal variation on treatment outcomes and the identification of canal variation will be discussed. This book serves as an essential resource for endodontists, general dentists, and dental students seeking to stay at the forefront of endodontic practice.