Since the first edition of this book in 1995, there has been a worldwide innovation-led economic boom and a subsequent slump, meaning enormous change has also occurred at the level of regional economies. The new edition registers this change and provides an interesting test of the robustness of the original arguments in the book. Not least, more industrial policy making is influenced by the RIS analysis, and many national and regional governments have adopted RIS approaches, along with related instruments like promotion of industry clusters, academic entrepreneurship, regional venture capital and science-led development strategies.