After thirty-five preceding sets of practical exercises laid forward in preceding manuscripts, I have extended from my core ICT academic and research experience to produce this manuscript. Here, a successive set of 25 cohesively written practical exercises in softwares, directly related to Molecular Bioinformatics, is laid forward, in a similar style as in the preceding manuscripts. Such exercises apply better to beginner levels in university courses. Of course, its applicability to advanced level courses may be appreciated by many academicians to their discretion. It is retained here that adaptations of these exercises by academicians to their requirements is very possible. It is recommended for students to devise good/workable summary sheets for each exercise, along with writing proper report and referencing needed. For each exercise, a share of analysis is required to develop thinking and critical/professional abilities. Most exercises are devised for computers/laptops along with currently trending smart phones/tablets. Students must communicate properly with their coach, who in turn, are recommended to perform judicious follow-ups.