This proceedings volume highlights the role and importance of Operational Research (OR) in the digital era and the underlying ICT challenges. The selected papers cover recent advances in all branches of operational research, mathematical modeling and decision making. It covers a wide range of key areas from digital economy, to supply chain management, and also finance. The book adopts an applied perspective that covers the contributions of OR in the broad field of business and economics linked with the discipline of computer science. The chapters are based on papers presented at the 6th International Symposium&28th National Conference on Operational Research. Although the conference is organized by the Hellenic Operational Research Society (HELORS), the contributions in this book promotes international co-operation among researchers and practitioners working in the field.