In this issue of Cardiology Clinics, guest editors Drs. Sharmila Dorbala and Piotr Slomka bring their considerable expertise to the topic of Nuclear Cardiology. Top experts in the field cover key topics such as advances in single-photon emission computed tomography hardware and software; technical aspects of cardiac PET; novel PET applications and radiotracers of imaging cardiovascular pathophysiology; radionuclide tracers for myocardial perfusion imaging and blood flow quantification; and more.• Contains 16 relevant, practice-oriented topics including artificial intelligence in nuclear cardiology; what is new in risk assessment in nuclear cardiology; radionuclide assessments and imaging for various conditions; low radiation dose myocardial perfusion imaging; myocardial perfusion imaging with calcium score; and more• Provides in-depth clinical reviews on nuclear cardiology, offering actionable insights for clinical practice• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews