This issue of Sleep Medicine Clinics, guest-edited by Drs. Amen Sergew and Lisa F. Wolfe, focuses on Noninvasive Ventilation and Sleep Medicine. This issue is one of four selected each year by series Consulting Editor, Dr. Teofilo Lee-Chiong. Articles include: Obesity hypoventilation - Traditional vs Non Traditional Populations; Spinal cord injury; Peri-Operative Care and Medication Related Hypoventilation; Lifetime Care of Duchenne Muscular Dystrophy; Management of Chronic Respiratory Failure in COPD - High and Low Intensity Ventilation; Management of Rare Causes Pediatric Chronic Respiratory Failure; Noninvasive Ventilator Management of ALS - Bulbar vs non Bulbar; Parsonage Turner; Noninvasive Ventilator Devices and Modes; Tailoring the Sleep Lab for Chronic Respiratory Failure; Long-Term Follow Up of Noninvasive Ventilation: Downloads and Troubleshooting; Extubating to Noninvasive Ventilation – NIV from ICU to Home; and From Tracheostomy to Noninvasive Ventilation – NIV from Long Term Acute Care to Home.