Get ready for a story so epic it could only unfold in the corridors of the world's largest museum – the SmithsonianInstitution. Museum guard-turned entrepreneur Larry Daly discovers that his favorite exhibits, and some of hisbest friends, from New York's Natural History Museum are being shipped off to the archives at the Smithsonian.Larry gets a distress call from the miniature cowboy, Jedediah, reporting that Egyptian ruler Kahmunrah and atrio of heinous henchmen – namely Ivan the Terrible, Napoleon and Al Capone – are plotting to take over themuseum, then the world. Speeding to the nation's capitol, Larry is clearly in over his head. But with someimpressive new pals, including the irrepressible Amelia Earhart, along with familiar friends Teddy Rooseveltand Octavius, Larry will stop at nothing to restore the Smithsonian before dawn.