Disorder-specific psychotherapeutic treatment programs, such as interpersonal psychotherapy or cognitive behavioral therapy, have proven effective in the inpatient treatment of depression and are now considered state of the art in depression treatment. Nevertheless, these interventions have their limitations when it comes to comorbidities and underlying pathologies, such as a lack of empathy or emotion regulation. In order to do justice to the complexity of depressive disorders requiring inpatient treatment and the implementation aspect of the many forms of therapy, a modular organizational principle is useful, which enables a pragmatic structuring of established therapeutic interventions. For the interpersonal module group described here, modules from CBASP (Cognitive Behavioral Analysis System of Psychotherapy), IPT (Interpersonal Psychotherapy), and mindfulness are systematically combined in a group format.