In 2022, how are women in STEM (science, technology, engineering and mathematics) faring? The Manifesto about Women in STEM is a collection of 50 texts that speak to the population at large. It brings together the thoughts of several authors, including individuals (both women and men) and groups from the school, university and private sector realms, who work with women in STEM in French-speaking Canada. This Manifesto is intended to be positive and impactful, even if work still remains to be done to achieve equity and equality. Several important issues are still current, such as workfamily balance and motherhood without penalty. Issues such as intersectionality, EDI (equity, diversity and inclusion) and the impact of the COVID-19 pandemic on women in STEM are also explored. There are texts that address the intersection of STEM and each of health, the arts, education and philosophy. Others deal with women who experience multiple forms of discrimination, for example Indigenous women and non-heterosexual women in STEM. Pioneers relate their obstacle-ridden but fulfilling journeys. Seven recommendations are proposed for a society looking to achieve equity, diversity and inclusion of women in STEM in an intersectional perspective.