This study examines the relationship between macroeconomic factors and non-performing loans (NPLs) in Southeast European Countries from 2013 to 2022. Utilizing econometric models like fixed effects, Hausman Taylor-IV, and GMM, it identifies GDP growth and inflation as negatively related to NPLs, while unemployment and credit growth have positive relationships. The research also explores how NPL feedback affects these macroeconomic factors, demonstrating a two-way interaction. Insights contribute to understanding financial stability in the region and offer policy recommendations to manage NPL levels effectively, improving banking resilience and economic activity.