This book covers a wide range of stateoftheart methodologies and detailed prools currently used to study the actions that lipidactivated nuclear receptors and their coregulators have in tissues and immune cell types considered classic metabolic “powerhouses”. This includes the liver, adipose tissue, and monocytes/macrophages present in these and other metabolic tissues. While the main focus is on the oxysterol receptor or Liver X Receptor (LXR), the majority of the methods described can be easily applied to multiple nuclear receptors, as well as to other tissues or cell types. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, stepbystep, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cuttingedge, LipidActivated Nuclear Receptors: Methods and Prools serves as an ideal guide for researchers pursuing the vital study of nuclear receptor biology and beyond.
This book covers a wide range of stateoftheart methodologies and detailed prools currently used to study the actions that lipidactivated nuclear receptors and their coregulators have in tissues and immune cell types considered classic metabolic “powerhouses”. This includes the liver, adipose tissue, and monocytes/macrophages present in these and other metabolic tissues. While the main focus is on the oxysterol receptor or Liver X Receptor (LXR), the majority of the methods described can be easily applied to multiple nuclear receptors, as well as to other tissues or cell types. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, stepbystep, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cuttingedge, LipidActivated Nuclear Receptors: Methods and Prools serves as an ideal guide for researchers pursuing the vital study of nuclear receptor biology and beyond.
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