This is a user-friendly manual of Interpersonal Psychotherapy used to treat pregnant or postpartum women who are suffering from depression. Interpersonal Psychotherapy for Perinatal Depression (IPT-P) is a brief weekly psychotherapy treatment of 12-16 weeks that has demonstrated success in several clinical trials supported by the National Institutes of Mental Health. The purpose of this IPT-P manual is to provide mental health workers including psychiatrists, psychologists, psychiatric nurses, social workers, and mental health counselors with step-by-step instructions.