This book constitutes the proceedings of the 24th International Conference on Information Processing in Medical Imaging, IPMI 2015, held at the Sabhal Mor Ostaig College on the Isle of Skye, Scotland, UK, in June/July 2015. The 22 full papers and 41 poster papers presented in this volume were carefully reviewed and selected from 195 submissions. They were organized in topical sections named: probabilistic graphical models; MRI reconstruction; clustering; statistical methods; longitudinal analysis; microstructure imaging; shape analysis; multi-atlas fusion; fast image registration; deformation models; and the poster session.