This research presents a Model of Humanistic Buddhism and the Holistic Health, which provides a profound and unique perspective on exploring the path of holistic health. Smṛtyupasthāna (Four Mindfulness) is an effective way to manage worries, allowing us to be free from worries, stay away from upside-down dreams, and achieve a state of freedom. In this model: (1) Kāyānupassanā and Physical Well-being, (2) Vedanānupassanā and Spiritual Well-being, (3) Cittānupassanā and Mental Well-being, and (4) Dhammānupassanā and Social Well-being. The Four Mindfulness Practices of Humanistic Buddhism provide us with valuable tools and ways to improve the holistic health and cope with the challenges and difficulties in life. Through spiritual practice and practice, we can achieve holistic health at the individual, physical, spiritual and social levels. Master Hsing Yun said that in the process of practicing the "Four Mindfulness", we can get rid of attachment to "I", including self-love, self-arrogance, self-view and ignorance. Eventually, we can achieve spiritual peace and self-liberation.