This book constitutes the refereed proceedings of HCI in Work and Learning, Life and Leisure, held as the 6th Symposium of the Workgroup Human-Computer Interaction and Usability Engineering of the Austrian Computer Society, USAB 2010, in Klagenfurt, Austria, in November 2010. The 10 revised full papers and 10 revised short papers presented were carefully reviewed and selected from 55 submissions. An additional number of 13 papers deal with two special thematic sessions UXFUL and WIMA. The papers are organized in topical sections on psychological factors of HCI; e-health and HCI; enhancing the quality of life of elderly people; supporting fellow humans with special needs; teaching virtual/mobile learning; enhanced and new methods in HCI research; enabling user experience with future interactive learning systems (UXFUL 2010); and interactive multimedia applications (WIMA).