The fourth edition of this textbook offers a structured introduction to global supply chain and operations management (SCOM), combining value creation networks and operational processes. It explains quantitative and organizational methods for planning and control of material, information, and financial flows in supply chains. Each chapter begins with an introductory case study, while numerous examples from various industries and services help to illustrate the key concepts. The book explains how to design operations and supply networks and collaborate with suppliers and customers. It shows how to balance supply and demand, a core aspect of tactical planning, before turning to the allocation of resources to meet customer needs. In addition, the book covers some advanced topics in SCOM, such as supply chain resilience, sustainability, Industry 4.0, artificial intelligence, and digital twins. Providing readers with a working knowledge of global supply chain and operations management, with a focus on bridging the gap between theory and practice, this textbook can be used in core, specialized, and advanced classes alike. It is intended for a broad range of students and professionals in supply chain and operations management.