With their groundbreaking building design for Scott Hall—a recently completed Nano-Bio-Energy Technologies Building at Carnegie Mellon University—architects Michelle LaFoe and Isaac Campbell show how their studio’s outside-the-box thinking and imaginative problem solving yielded an innovative design vision for this prestigious project. By weaving together architecture, contemporary fabrication technology, and an ingenious campus planning approach, they reveal how they won an invited national design competition with a design reverent to its designated place. With numerous illustrated examples, the authors share their studio’s creative process and demonstrate how they reimagined the prescribed planning strategy for Scott Hall to produce a unique, energy efficient design for the building, its complex site, and its demanding research program.