This book is dedicated to the general study of fluid structure interaction with consideration of uncertainties. The fluid-structure interaction is the study of the behavior of a solid in contact with a fluid, the response can be strongly affected by the action of the fluid. These phenomena are common and are sometimes the cause of the operation of certain systems, or otherwise manifest malfunction. The vibrations affect the integrity of structures and must be predicted to prevent accelerated wear of the system by material fatigue or even its destruction when the vibrations exceed a certain threshold.