Shadow That Walks, warrior of the Notsoteka Comanche, has had a vision; a vision of war. His family has been taken from him, and he will have vengeance. There can no longer be peace.
Sheriff Jackson Cole has known war and wants only to live in peace, but a new war has come, and he is forced to put his trust in a man from his past he hoped to never see again.
Colonel Ranald Mackenzie and the men of the Fourth Calvary have been sent to the Panhandle of Texas, to the Comancheria; home of the Kwahadi, the last of the free Comanche. His mission is to force their surrender and put an end to the raids on the citizens of Texas.
Quanah, war chief of the Kwahadi, stands ready to teach the soldiers a lesson in Comanche warfare and change the hunters into the hunted.
Based on actual events, First Kill tells the story of the struggle to bring the fiercest of the plains tribes into submission, the struggle of the Comanche to rid their lands of the encroaching invaders, and the settlers caught in between.