Based on a true story, Fatal Frame recounts Miku's investigation for her brother Mafuyu when he goes missing for two weeks. Her latest clue leads her to the abandoned Himuro mansion. Mafuyu was investigating the disappearance of three people, one of which was the famous writer Junsei Takamine, who was also his mentor. The townfolks, however, aren't being cooperative with the investigation, so he decides to explore the mansion alone. Gifted with a supernatural sixth sense, Miku is worried about her brother's fate, so she enters the mansion in search of him.