Written for researchers and postgraduate students with a background in physics or applied mathematics and a desire to apply their skills to problems in the life sciences, this beautifully illustrated and stimulating book develops an understanding of the gene—to—trait problem in the context of evolutionary dynamics, from the modern perspective of integrative biology. The gene—to—trait problem resides at the heart of a great many questions in biology. The author presents both elementary and advanced material in a way that brings out how this gene—to—trait problem is treated in the contexts of bioinformatics and evolutionary dynamics. Key ideas and techniques that underlie some of the most—used bioinformatics methods are discussed in an integrative context and a wide range of examples of mathematical models of living things is developed in an evolutionary framework.