In a fast changing global economy governed by Enterprise Services and the Future Internet, enterprises and virtual factories will self-organize in distributed, interoperable, innovation Ecosystems where the issues of Enterprise Interoperability need to be solved in a multi-view of information, services and processes throughout Enterprise Networks. The book constitutes the proceedings of five workshops co- located with the Fifth IFIP Working Conference IWEI 2013. It contains the presented peer reviewed papers and summaries of the workshop discussions. Complementing the IWEI Conference program, the workshops aimed at exploiting new issues, challenges and solutions for Enterprise Interoperability and Manufacturing Eco Systems. The scope of the workshops spanned over a range of interoperability issues in Service Science and innovation, Model Driven Service Engineering Architectures, Service Modelling Languages, reference ontology for manufacturing , Case studies and tools particularly for SMEs, Business – IT alignment and related Standardization.