This study investigated the impact of Information and Communication Technology (ICT) adoption on the competitive advantage of Yemeni universities, mediated by education quality. A questionnaire was distributed to a sample of 622 staff and students from the engineering and computer science colleges of Hadhramout University and the University of Science and Technology, out of a total of 651, achieving a 95.6% response rate. Results revealed a high level of interest in the study variables (ICT, education quality, and competitive advantage). A significant positive relationship was found between ICT adoption and competitive advantage, with education quality mediating this relationship. The study recommends developing a comprehensive ICT strategy aligned with university goals, prioritizing technologies that enhance teaching and learning, providing ICT training for faculty and staff, and encouraging technology integration in teaching methods.