This monograph contains an in-depth and coherent treatment of dimension-reduced modeling of blood flows on the level of large vessels (macrocirculation). The authors reduce the complexity by combining a one-dimensional Navier-Stokes equation and a simplified FSI-concept. The influence of omitted vessels, which are subsequent to the outlets of larger vessels, is accounted for by systems of ordinary differential equations (0D models). The target audience primarily comprises research experts in the field of biomedical engineering, but the book may also be beneficial for graduate students alike.