This book constitutes the refereed proceedings of the 15th International Conference on Cognitive Radio-Oriented Wireless Networks, CROWNCOM 2020, held in Rome, Italy, in November 2020. Due to COVID-19 pandemic the conference was held virtually. The 13 revised full papers were selected from 28 submissions and present all major technical aspects related to cognitive radio and networks. The papers are organized in four sessions: spectrum sensing and environment awareness; resource sharing and optimization; verticals and applications; business models and spectrum management.