When a prisoner transport bus from the Federal Correctional Institute at Pekin crashes, four dangerous fugitives are on the run. Deputy U.S. Marshal Tim Noonon and his squad are called in to begin the search for the fugitives, but somebody unexpected shows up as well. Six agents from the CIA arrive on scene to take over the search for two of the fugitives. Deputy Noonan butts heads with the CIA Agent in charge, Special Agent Jane Donner, as the case progresses. Constantly stepping on toes, Agent Donner does what she needs to in order to get the job done. Making friends is not her job, yet she and the other Agents can't help but come to like the Marshals. What she doesn't expect is fugitive Rambo Tate. Rambo Tate, a drug dealer and murderer out of Boston, knows just who Agent Donner really is. If he is allowed to return to Boston, he may just blow Agent Donner's cover, putting not only her life, but the life of those around her in danger. It's a race against the clock as the Marshals and CIA must work together to find the missing criminals. Can the Marshals overcome their distrust of the CIA or will the fugitives disappear?