This two-volume set LNCS 14509-14510, constitutes the refereed proceedings of the First International Conference on Artificial Intelligence Security and Privacy, AIS&P 2023, held in Guangzhou, China, during December 3–5, 2023. The 40 regular papers and 23 workshop papers presented in this two-volume set were carefully reviewed and selected from 115 submissions. Topics of interest include, e.g., attacks and defence on AI systems; adversarial learning; privacy-preserving data mining; differential privacy; trustworthy AI; AI fairness; AI interpretability; cryptography for AI; security applications.