This book approaches three important aspects related with urban regeneration such as research, innovation and challenges. In light of its growing interdisciplinarity, the selected contributions extend the debate to the importance of the cooperation between various disciplines, attention to the latest design and technological trends, as well major inclusivity of citizens for a correct decision-making process leading afterwards into successful development, test and implementation of innovative solutions. An important focus will be set on the important role innovations play in the preservation and management of heritage sites in response to the climate and urban challenges encountered. Also, this contribution aims to transmit the importance of local interventions in the achievement of urban regeneration as an impulse for the achievement of the common global climate goals in the years ahead.