This issue of Medical Clinics, guest edited by Dr. Cheston B. Cunha, is devoted to Antimicrobial Stewardship. Articles in this issue include: Principles of Antimicrobial Stewardship; Antibiotic Resistance in Stewardship; Therapy of Resistant Organisms: A Stewardship Approach; Optimal Antibiotic Dosing Strategies; The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship; Role of Education in Antimicrobial Stewardship; Role of the Hospital Epidemiologist in Antimicrobial Stewardship; Role of the Clinical Microbiology Laboratory in Antimicrobial Stewardship; Role of New and Rapid Diagnostics In Antimicrobial Stewardship; Antimicrobial Stewardship in the Community Hospital; Antimicrobial Stewardship in Long-Term Care Facilities; Role of the Pharmacist in Antimicrobial Stewardship; Pharmacoeconomic Considerations of Antimicrobial Stewardship Programs; Principles of IV-to-PO Switch and PO therapy; Role of Technology in Antimicrobial Stewardship; and Metrics of Antimicrobial Stewardship Programs.