This book contains 26 papers describing research in the do- main of Artificial Intelligence in Medicine. The papers are grouped around the following themes: Methodology, knowledge representation, clinical applications, modelling, uncertain- ty management, knowledge acquisition, and the user perspec- tive. The book gives an overview of the current state of AI in medicine research in Europe. It presents several techni- ques and methods that are likely to play an important role in future applications. In the section on clinical applica- tions not only existing systems are described, but results of evaluation studies are presented as well.