This book constitutes the refereed proceedings of the First International Conference on Advanced Research in Technologies, Information, Innovation and Sustainability, ARTIIS 2021, held in La Libertad, Ecuador, in November 2021. The 53 full papers and 2 short contributions were carefully reviewed and selected from 155 submissions. The volume covers a variety of topics, such as computer systems organization, software engineering, information storage and retrieval, computing methodologies, artificial intelligence, and others. The papers are logically organized in the following thematic blocks: ​Computing Solutions; Data Intelligence; Ethics, Security, and Privacy; Sustainability.