An autoimmune disorder in which the connective tissue of the body gets affected is known as systemic sclerosis or systemic scleroderma. It is classified into two forms - non-systemic and systemic. The systemic condition can be limited or diffuse. Limited scleroderma is characterized by Raynaud's phenomenon, sclerodactyly, telangiectasia, esophageal dysfunction and calcinosis. Diffuse scleroderma, in contrast, can cause pulmonary, musculoskeletal, renal and gastrointestinal complications. The prognosis of systemic sclerosis is different for the diffuse and limited forms of the disease. So far, the underlying cause of sclerosis is not understood. There is no cure for scleroderma but its symptoms are managed with therapy. This book provides significant information of the modern research dimensions in systemic sclerosis to help develop a good understanding of its assessment and clinical management. It explores all the important aspects of systemic sclerosis in the present day scenario. For someone with an interest and eye for detail, this book covers the most significant topics in immunology.